Washington, D.C. - [July 28, 2025] —UsAgainstAlzheimer’s applauds exciting new findings showing that many Americans can take clear, evidence-backed steps to reduce their risk for developing Alzheimer’s. These early results, released today at the Alzheimer’s Association International Conference (AAIC) 2025, come from the U.S. Protect through a Lifestyle Intervention to Reduce Risk (POINTER) study a landmark effort offering strong clinical evidence that healthy actions can help shield the brain from decline. These findings mark a major milestone in the fight to end Alzheimer’s, showing that older adults at elevated risk who stay active, eat well, engage their minds, and stay socially connected can significantly lower their chances of cognitive decline. 

“The results from the U.S. POINTER study provide the U.S. with a roadmap to reduce the burden inflicted by Alzheimer’s disease,” said George Vradenburg, chairman and co-founder of UsAgainstAlzheimer’s. “For the first time in the United States, we have large-scale clinical proof showing that how we live, what we eat, how we move, how we connect, can all make a meaningful difference in protecting our brains. This is a turning point: It’s no longer just about hope; it’s about action rooted in science. And the action must start now. Individuals and families must be empowered to take steps toward brain health, while Congress and the administration must ensure that everyone, especially those most at risk, has access to the resources and support needed to make brain-healthy living a reality.”

The U.S. POINTER study included over 2,000 participants across multiple sites in the country. It compared two groups: one participating in a structured program and the other following a self-guided approach. Both interventions were designed to assess whether a combination of physical activity, nutritional guidance, cognitive training, social activities and management of heart-health risk factors protected cognition in healthy older adults with an increased risk of cognitive decline. The study also used advanced imaging tools, such as amyloid and tau PET scans and MRI, to track biological changes in the brain, providing further insight into the connection between lifestyle and brain health.

UsAgainstAlzheimer’s has championed risk reduction as a key pillar in the fight to end Alzheimer’s. These findings are a resounding validation that low-cost, preventive strategies work—and could be a game-changer in the national response to Alzheimer’s.