Aduhelm (Aducanumab) and UsAgainstAlzheimer’s

Aducanumab is a treatment for early Alzheimer’s disease that is intended to slow the progression of the disease. It was approved by the Food and Drug Administration (FDA) in June, 2021, and is being marketed under the name Aduhelm. UsAgainstAlzheimer’s (UsA2) urged the FDA to approve aducanumab.

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"Biogen, Medicare, private insurers, and the FDA must immediately address patient concerns about affordability, equity, effectiveness, and whether [Aduhelm] is right for them. UsAgainstAlzheimer’s stands ready to help."

Read UsAgainstAlzheimer's full statement - New Alzheimer’s Treatment Must Be Affordable and Accessible; with Faster and More Inclusive Phase 4 Confirmatory Trial

"We urge the FDA to approve aducanumab and put in place a platform to assess the real-world experience with the drug by persons in the early stages of Alzheimer’s disease." (Read the full letter UsA2 sent to the FDA.)

George Vradenburg and Russ Paulsen

Co-Founder and Chairman, UsAgainstAlzheimer's and Chief Operating Officer, UsAgainstAlzheimer's.

“Alzheimer’s is a disease of greater prevalence and greater lethality than Covid-19. This is an ongoing pandemic. Its cost to America in terms of direct medical costs is significantly higher than cancer.” (Read the full article in Barron's.)

George Vradenburg

Co-Founder and Chairman, UsAgainstAlzheimer's

About Aducanumab

  • Aducanumab is an approved treatment for early Alzheimer’s disease that is intended to slow the progression of the disease. Aducanumab does this by promoting clearance of amyloid beta plaques, a hallmark of Alzheimer’s, from the brain. It has the potential to slow the rate of cognitive and functional decline in persons in the earlier stages of Alzheimer’s and may help preserve the cognitive abilities and functions of these patients for a longer time.

  • Aducanumab, which has been developed by Biogen, was approved in June, 2021 by the Food and Drug Administration. Now being marketed under the name Aduhelm, it is the first disease-modifying therapy approved for use in the U.S.

  • Aducanumab is approved for use by people living with early-stage Alzheimer’s disease and mild cognitive impairment, which are the groups in the clinical trials. The FDA approval calls for a post-marketing confirmatory study to see how the drug therapy works for different groups.

Aducanumab and UsAgainstAlzheimer’s

UsAgainstAlzheimer’s (UsA2) urged the U.S. Food and Drug Administration to approve aducanumab. By delaying the progression for people in the early stages of the disease, this drug therapy will give people more time to live independently and perform daily activities longer.

To people living with the disease and their caregivers, every single day matters. Approval of this drug is a powerful sign of hope for people living with Alzheimer’s after years of disappointment.

UsA2 also believes that FDA approval of aducanumab would have a ripple effect on pharmaceutical innovation that could spark additional investment by other companies in disease-modifying treatments and therapies.

Following FDA approval of the drug, UsAgainstAlzheimer’s has pushed for additional steps to make Aduhelm affordable and accessible for anyone who needs it and has supported Medicare coverage for the treatment, which has a list price of $56,000 a year. UsAgainstAlzheimer’s also has called on Biogen to include many more Black Americans and Latinos in the post-approval confirmatory study, and to complete that Phase 4 clinical trial faster than the nine years allowed by the FDA.

Resources

  • Resources

    Letter to HHS Sec. Becerra on Prevention and Risk Reduction of Alzheimer's

  • Resources

    Summary of Findings: UsAgainstAlzheimer’s Survey on Early Diagnosis and Attitudes Toward Use of a Disease-Modifying Alzheimer’s Therapy

  • Resources

    2020 Annual Report

    In these pages, you will find highlights of the game-changing accomplishments and tremendous progress of UsAgainstAlzheimer's and our partners in the year of 2020. 

  • Resources

    A-LIST Pulse of the Community: Volume 8, June 2021

  • Resources

    A-LIST Pulse of the Community: Volume 8, June 2021

    The UsAgainstAlzheimer’s A-LIST® is an online community of more than 8,600 people living with Alzheimer’s and other dementias, current and former caregivers, and those concerned about brain health, who have...

  • Resources

    Prevention

    Leave behind stressing the need for a national Alzheimer's prevention goal because cognitive decline is not inevitable.

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