Insulin Spritz Shows Promise for People With Early Signs of Alzheimer's

A small study published Tuesday in the Archives of Neurology found preliminary evidence that spraying critical insulin deep into the nose could help delay the onset of Alzheimer's disease. Ray Suarez speaks with University of Washington School of Medicine professor Suzanne Craft, who led the study.

SNIFF: Study of Nasal Insulin to Fight Forgetfulness

SNIFF: Study of Nasal Insulin to Fight Forgetfulness

What do Participants Do?
Read and sign a consent form.
Give family and Medical History.
Answer questions that test your memory, thinking, mood, and concentration.
Complete a brief neurological examination.
Give permission to review the medical records of the individual with memory and thinking problems.
Provide a blood, urine and lumbar fluid sample.
Receive a free ECG (a look at your heart)
Have a study partner- someone who you see regularly who can answer questions about your health
Monetary compensation may be available at certain sites
Why is this Study Important?
The purpose of the SNIFF study is to find out whether a type of insulin, when administered as a nasal spray, improves memory in adults with a mild memory impairment or Alzheimer’s disease. There is growing evidence that poor regulation of insulin may make it difficult for the brain to function optimally and may contribute to the development of Alzheimer’s. SNIFF will test a therapy aimed at using insulin to see if these deficiencies can be corrected.
What are the study facts?
Study participation is voluntary.
Joining the study will not affect your healthcare or insurance.
information is confidential.
There is no cost to participate.
A participant may withdraw from the study at any time.
Travel to the research center is required for testing and follow-up.
Participants will receive periodic updates from the Project Director
Who can join the Study?

You may be eligible to join the SNIFF study if you:

Have a diagnosis of a mild cognitive impairment or possibly mild Alzheimer’s Disease
Fluent in English or Spanish
Have a partner available to attend all clinic appointments and available to supervise drug administration twice a day
Stable medical condition for three months prior to screening visit
Stable medications for four weeks prior to screening visit
Do NOT take drugs for diabetes (type I or II)
Willing and able to undergo clinic assessments (for example -- blood and urine lab tests, MRI, lumbar puncture, ECG, neuropsychological tests)
Enroll in the Study Today!
List of study locations at bottom (need to have ability to link to each location with the name of the chief researcher.[SNIFF ADRC Page includes list of sites with numbers. Need to add a person’s name and email.
Who is sponsoring this Study?
This study is being conducted by the Alzheimer’s disease Cooperative Study (ADCS) through a grant from the National Institute on Aging (NIA), one of the National Institutes of Health (NIH).
There are many other research studies available in throughout the United States. To learn more about these studies go to: [provide link to I’m in or the Clinical Trials Engagement Network]
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StateCitySitePhone
AZPhoenixBanner Alzheimer's Institute(602)839-6853
AZSun CityBanner Sun Health Research Institute(623)832.8790
CAIrvineUniversity of California, Irvine(949)824-8726
CALa JollaUniversity of California, San Diego(858)246-1303
CTNew HavenYale University School of Medicine(203)764-8106
DCWashingtonGeorgetown University(202)687-0413
DCWashingtonHoward University(202)865-3776
FLJacksonvilleMayo Clinic, Jacksonville(904)953-7989
FLTampaUniversity of South Florida - Health Byrd Alzheimer Institute(813)974-4904
ILChicagoRush University Medical Center(312)563-4111
ILChicagoNorthwestern University(312)503-2486
INIndianapolisIndiana University(317)963-7418
KSKansas CityUniversity of Kansas(913)945-7676
KYLexingtonUniversity of Kentucky(859)323-3145
MABostonBrigham and Women's Hospital(617)732-8085
MDBaltimoreJohns Hopkins University(410)550-9053
MNRochesterMayo Clinic, Rochester(507)293-4726
MOSt. LouisWashington University, St. Louis(314)286-2683
NCWinston-SalemWake Forest University Health Sciences(336)713-8847
NYNew YorkMount Sinai School of Medicine(212)659-8885
NYNew YorkNew York University Medical Center
NYRochesterUniversity of Rochester Medical Center(585)760-6562
OHClevelandCase Western Reserve University(216)464-6474
ORPortlandOregon Health & Science University(503)494-9399
RIProvidenceRhode Island Hospital(401)444-2484
TXDallasUniversity of Texas, Southwestern MC at Dallas(214)648-9331
TXHoustonBaylor College of Medicine(713)798-4734
WASeattleUniversity of Washington(206)764-2339