The A4 Study

Hear from Dr. Reisa Sperling and other Alzheimer's experts about what makes the A4 study so unique and why now is the time to volunteer.

The A4 Study

The A4 Study

What do Participants Do?
Read and sign a consent form.
Give family and medical History.
Answer questions that test your memory, thinking, mood, and concentration.
Complete a brief neurological examination.
Provide a blood, urine and lumbar fluid sample.
Receive a free once a month IV of the treatment or placebo for 39 months
Receive a free ECG (a look at your heart)
Receive a free PET scan and MRI (pictures of your brain)
Have a study partner- someone who you see regularly who can answer questions about your health and memory function
Why is this Study Important?
Alzheimer’s-related brain changes take place years, even decades before symptoms appear. Scientists are hopeful that if they can intervene at the earliest possible stage, they may be able to stop or slow the progression of the disease. The A4 Study is an important clinical trial in several respects. First, it will see if they can prevent memory loss from progressing into Alzheimer’s disease by treating older individuals who may be at slightly higher risk. Secondly, they have an ambitious goal of screening at least 1000 African Americans for the study to get the 100 who are the perfect fit. This is absolutely essential if we are to find out why African Americans are twice as likely to get Alzheimer’s disease. Less than 5 percent of those who participate in clinical trials are African Americans despite the fact that we make up over 13 percent of the U.S. population. To ensure that Alzheimer’s treatments are both safe and effective for all, including African Americans, we must significantly increase the number of minority research volunteers.
What are the study facts?
Study participation is voluntary.
All information is confidential.
There is no cost to the family.
A participant may withdraw from the study at any time.
The A4 study lasts for three and one half years and participants will be required to visit the research site once a month.
Monetary compensation is offered at many sites as well as reimbursement of transportation costs
Who can join the Study?

You may be eligible to join the A4 Study if you:

Are 65 to 85 years old
Have normal thinking and memory abilities for your age
Have a study partner (someone who has weekly contact with you and is willing to answer questions once a year).

Enroll in the Study Today!

Who is sponsoring the study?
The A4 study is a landmark public-private partnership, funded by the National Institute on Aging, Eli Lilly and Company, and several philanthropic organizations. The A4 study is coordinated by the Alzheimer's Disease Cooperative Study, located at the University of California, San Diego.
ALBirminghamUniversity of Alabama, BirminghamDenise Ledlow(205)
AZPhoenixBanner Alzheimer's InstituteCandy Monarrez(602)
AZSun CityBanner Sun Health Research InstituteZoran Obradov(623)
CAIrvineUniversity of California, IrvineCatherine M McAdams-Ortiz(949)
CAIrvineUniversity of California, Irvine - Brain Imaging CenterAndrea Sabrina Weideman(714)
CAIrvineUC Irvine - Institute for Memory Impairments & Neurological DisordersBeatriz Yanez(949)
CALa JollaUniversity of California, San DiegoHelen Vanderswag(858)
CALos AngelesUniversity of Southern CaliforniaMauricio Becerra(323)
CALos AngelesUniversity of California, Los AngelesCeline Ossinalde(310)
CAPalo AltoStanford University School of MedicineEmily Gere(650)
CASacramentoUniversity of California, DavisKatharine Vieira(925)
CASan FranciscoUniversity of California, San FranciscoEmmeline L. Chuu(415)
CTNew HavenYale University School of MedicineBarbaralynn Moseman(203)
DCWashingtonGeorgetown UniversityErica Christian(202)
DCWashingtonHoward UniversityOludolapo O. Ogunlana(202)
FLJacksonvilleMayo Clinic, JacksonvilleDana Lynn Haley(904)
FLMiami BeachWien Center for Clinical ResearchMaria T Greig-Custo(305)674-2121 Ext.
FLPalm BeachPremiere Research InstituteTeresa Villena(561)845-0500 ext
FLTampaUniversity of South Florida - Health Byrd Alzheimer InstituteJill aka Ardila Smith(813)
GAAtlantaEmory UniversityGail Schwartz(404)
IAIowa CityUniversity of IowaKaren Ekstam Smith(319)
ILChicagoNorthwestern UniversityKristine Lynn Lipowski(312)
ILChicagoRush University Medical CenterLindsay M Pluff(312)
INIndianapolisIndiana UniversityNancy McClaskey(317)
KSKansas CityUniversity of KansasBecky Rebecca Jo Bothwell(913)
KYLexingtonUniversity of KentuckyHeather D Nichols(859)
MABostonBrigham and Women's HospitalAlison Pietras(617)
MABostonBoston UniversityJane Mwicigi(617)
MDBaltimoreJohns Hopkins UniversityJulia J Pedroso(410)
MIAnn ArborUniversity of Michigan, Ann ArborJoanne L Lord(734)
MNRochesterMayo Clinic, RochesterSara S. Mason(507)
MOSt. LouisWashington University, St. LouisPamela Millsap(314)
NCWinston-SalemWake Forest University Health SciencesErin caulder(336)
NEOmahaUniversity of Nebraska Medical CenterBarbara Bayer(402)
NVLas VegasCleveland Clinic Lou Ruvo Center for Brain HealthMichelle B Sholar(702)
NYAmherstDent Neurologic InstituteCaroline R Kumm(716)
NYAmherstDent Neurologic InstituteMichelle Rainka(716)
NYNew YorkWeill Cornell Memory Disorders ProgramErin Hibbard(212)
NYNew YorkMount Sinai School of MedicineMichael T Kinsella(212)
NYNew YorkColumbia UniversityRuth Tejeda(212)
NYNew YorkNew York University Medical CenterChristina Michel(212)
NYOrangeburgNathan Kline Institute for Psychiatric ResearchVita Pomara(845)
NYRochesterUniversity of Rochester Medical CenterSusan Salem-Spencer(585)
OHClevelandCase Western Reserve UniversityMaria Gross(216)
OKTulsaTulsa Clinical ResearchRita Smith(918)
ORPortlandOregon Health & Science UniversityElisabeth Loree(503)
PAPhiladelphiaUniversity of PennsylvaniaJessica Nunez-Lopez(215)
PAPhiladelphiaDrexel University College of MedicineKate Joan Bowen(215)
PAPittsburghUniversity of PittsburghKaty Marie Zorich(412)
RIProvidenceRhode Island HospitalMichele Astphan(401)
RIProvidenceButler Hospital Memory and Aging ProgramDiane Monast(401)
TXDallasUniversity of Texas, Southwestern MC at DallasKathleen Koch(214)
TXHoustonBaylor College of MedicineKimberley D Brown(713)
UTSalt Lake CityUniversity of UtahJosh Amaro(801)
WASeattleUniversity of WashingtonAnita Ranta(206)
WIMadisonUniversity of WisconsinZachary Zugin(608)256-1901 Ext.

Canada Clinical Study Research Sites Participating in the A4 Study:

University of British Columbia, Clinic for AD & RelatedVancouverBritish ColumbiaBenita Mudge(604)
Parkwood HospitalLondonOntarioPatricia Sargeant(519)685-4292 Ext.
Sunnybrook Health Sciences CentreTorontoOntarioJoanne Lawrence(416)
Toronto Memory ProgramTorontoOntarioAtif Shaikh(416)

Australia Clinical Study Research Sites Participating in the A4 Study:

University of MelbourneMelbourneVictoriaMaree Mastwyk+61 3 9389
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